Karlsruhe Institute of Technology
Loop formation in a simulated section of the genome. (detailed caption at the end of text; graphic: KIT)
There is more movement in our genome than we think. Almost half of the human genome consists of transposons - short DNA sequences capable of relocating within the genome. They "jump" from one place to another, not uniformly distributing across the genome, but often grouping together in clusters. Researchers at Karlsruhe Institute of Technology (KIT) have now discovered how this clustering occurs. This is made possible by a physical effect that results in local unfolding of the genome. The results were published in the Biophysical Journal. (DOI: https://doi.org/10.1016/j.bpj.2025.03.038 )
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