Regent Street is closed in both directions between George Street and Cleveland Street at Chippendale due to a building fire.
Motorists are advised to avoid the area.
Northbound motorists can use Cleveland Street and Abercrombie Street instead.
Southbound motorists can use Broadway and City Road.
Traffic is heavy in the area so motorists are advised to allow plenty of extra travel time.
Emergency services and traffic crews are attending.
For the latest traffic information, download the Live Traffic NSW app, visit www.livetraffic.com or call 132 701.
For the latest public transport information, visit www.transportnsw.info