Scientists from the University of Sheffield have been awarded £1.2 million to develop a drug to protect dopamine-producing brain cells and slow down the progression of Parkinson’s Disease.
The funding from Parkinson’s UK comes via the charity’s Virtual Biotech initiative, which is plugging the funding gap in drug development and fast-tracking the development of new treatments for people with Parkinson’s.
A team of world-leading researchers at the University of Sheffield’s Institute of Translational Neuroscience (SITraN), led by Dr Heather Mortiboys, has been working with experts from Parkinson’s UK to develop molecules that can boost the function of the brain’s energy-producing mitochondria to halt the degenerative disease – something no treatment can currently do.
Dopamine is a chemical which allows messages to be sent to the parts of the brain that help to coordinate movement. To do this effectively, the dopamine-producing brain cells need to be constantly active and they rely on mitochondria to function properly. Any disruption could lead to dysfunction and degeneration of the brain cells and eventual cell death. Parkinson’s is what happens when those cells die.
Earlier work from Dr Mortiboys, funded by a Parkinson’s UK Senior Fellowship grant, identified two molecules with excellent mitochondrial restoration properties.
The project continued with funding through the Virtual Biotech initiative and saw Dr Mortiboys work closely with Parkinson’s UK Drug Discovery experts. Together they made modifications to these molecules, which maximised their ability to boost the mitochondria without causing side effects. In a mould-breaking approach to drug discovery, scientists have been using cells from people with Parkinson’s and will continue to test molecules in these cells throughout and into the next phase of the project.
Dr Heather Mortiboys, Senior Lecturer at the University of Sheffield’s SITraN, said: “Two more people are diagnosed with Parkinson’s disease every hour – that’s 18,000 people every year. Causing a loss of physical movement and uncontrollable tremors, the disease will affect 145,000 people in the UK alone in 2020.
“We’re delighted to continue our work with Parkinson’s UK to refine these promising molecules to develop a treatment that could stop Parkinson’s in its tracks. The team has identified not only molecules which can restore mitochondrial function in dopaminergic neurons from people with Parkinson’s, but also a novel mechanism by which they do this.
“We’re progressing both a novel mitochondrial therapeutic target and novel molecules which act upon this target. The aim is to have a lead molecule which is active at the mitochondrial target, can restore mitochondrial function in dopaminergic neurons derived from people with Parkinson’s and is able to get into the brain in a whole organism.”