Positron emission tomography (PET) is a powerful tool for the visualization of metabolism, especially the measurement of glucose uptake in vivo. Previous studies have assessed glucose uptake in several tissues such as the brain, visceral adipose tissue, and liver using PET imaging. However, due to the inadequate axial field of view of the existing PET scanners, simultaneous measurement of glucose uptake in major organs and parts across the entire human body has not yet been achieved.
A recent study published in Life Metabolism provides an atlas of glucose uptake across the entire human body via the state-of-the-art total body PET/CT system. (https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/loac030/6775914)
The researchers used the uEXPLORER total-body PET/CT scanner to generate a detailed profile of glucose uptake across the entire human body (Figure 1), and then explored the effect of age, sex, and laterality on glucose uptake, as well as the differences of glucose uptake across the whole body between healthy and overweight groups.
This study has demonstrated the utility of PET/CT in the understanding of human metabolism and metabolomics. A glucose uptake atlas might also be useful in diagnosing and treating malignancies, obesity, diabetes, and other metabolic disorders.
