JAMA Network
About The Study: In this cohort study of 47,000 adults participating in the National Health and Nutrition Examination Survey, after accounting for demographic characteristics (e.g., age, race and ethnicity), behavioral factors (e.g., smoking, alcohol use), and chronic conditions (e.g., diabetes, hypertension), males had a 63% greater risk of all-cause mortality than females. These findings suggest that there may be intrinsic biological factors (sex hormones, chromosomes, or immune response) associated with sex differences in mortality. Further research should investigate the effects of sex-linked biological factors on mortality.
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