Giant Faba Bean Genome Sequenced

INRAE - National Research Institute for Agriculture, Food and Environment

Vicia faba L., commonly referred to as “faba bean” or “broad bean”, is known for its protein-rich seeds and its yield potential in agriculture. It is used for human consumption as well as for animal feed. It also provides much needed ecosystem services in the context of the transition to more sustainable farming systems. In particular, it is able to fix atmospheric nitrogen and acquire nutrients through beneficial interactions with soil bacteria or fungi, thus reducing the need for fertilisers.

Reconstructing the genome sequence of faba bean was a challenge as it consists of 13 billion nucleobases, at least 4 times larger than the human genome. The genetic information in faba bean is carried on only 6 pairs of chromosomes. Chromosome 1 (the longest) alone is the size of the 23 chromosomes in the human genome combined.

Recent advances in sequencing techniques have made it possible to obtain a high-quality assembly despite the richness of this genome in transposable elements, highly repeated and similar DNA sequences. An imbalance in the rates of amplification and elimination of some of these repeats has in fact been identified as the cause of the expansion in the size of the faba bean genome.

Through quantitative genetic approaches and mining of genome data, the consortium has for the first time identified the genes controlling traits of interest in this legume, such as seed size.

This now available new resource opens up new research prospects, in particular by comparing legume genomes with each other. In a context of high demand for plant proteins and changes in agricultural practices, it will also facilitate varietal selection for traits related to these issues.

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