https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/12/issue/12
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:
Evolution of drug regulations and regulatory innovation for anticancer drugs in China by Yang Liu, Ning Zhang, Cuicui Xie et al. (https://doi.org/10.1016/j.apsb.2022.08.004). This review is an overview of newly approved cancer drugs in China between 2005 and 2021, as a powerful illustration of how revolution in drug regulation has influenced the drug R&D in China.
Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein by Dongrong Yia, Quanjie Lia, Han Wang et al. (https://doi.org/10.1016/j.apsb.2022.05.023). Through structure-based virtual screening, this study reported that a natural compound berbamine hydrochloride can disrupt GPcl–NPC1 interaction, and strongly inhibited EBOV replication in vitro and in vivo.
Landscape of DILI-related adverse drug reaction in China Mainland by Jiabo Wang, Haibo Song, Feilin Ge et al. (https://doi.org/10.1016/j.apsb.2022.04.019). This study provides a whole epidemiological picture of L-ADR in mainland China and concluded that L-ADR has a persistent increase. This work provides a powerful tool to mine the potential hepatotoxic drugs in the future.
Other articles include:
Review Articles
Research and development of Chinese anti-COVID-19 drugs
Xiwei Ji, Xiangrui Meng, Xiao Zhu, Qingfeng He, Yimin Cui
Small molecule-based immunomodulators for cancer therapy
Yinrong Wu, Zichao Yang, Kui Cheng, Huichang Bi, Jianjun Chen
Harnessing the cyclization strategy for new drug discovery
Kai Tang, Shu Wang, Wenshuo Gao, Yihui Song, Bin Yu
Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
Yanyan Xu, Jingyuan Xiong, Xiyang Sun, Huile Gao
Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era
Hao Ling, Xinyu Lou, Qiuhua Luo, Zhonggui He, ... Jin Sun
Research and development of Chinese anti-COVID-19 drugs
Xiwei Ji, Xiangrui Meng, Xiao Zhu, Qingfeng He, Yimin Cui
Small molecule-based immunomodulators for cancer therapy
Yinrong Wu, Zichao Yang, Kui Cheng, Huichang Bi, Jianjun Chen
Harnessing the cyclization strategy for new drug discovery
Kai Tang, Shu Wang, Wenshuo Gao, Yihui Song, Bin Yu
Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
Yanyan Xu, Jingyuan Xiong, Xiyang Sun, Huile Gao
Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era
Hao Ling, Xinyu Lou, Qiuhua Luo, Zhonggui He, ... Jin Sun
Original Articles
Wan Li, Hongqing Cai, Liwen Ren, Yihui Yang, ... Jinhua Wang
Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer
Minmin Fan, Jian Gao, Lin Zhou, Wenwen Xue, ... Qiang Xu
Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development
Deying Yang, Xiang Luo, Qinghai Lian, Lingqiang Gao, ... Guochao Liao
Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents
Chengliang Sun, Yao Cheng, Xiaojia Liu, Gefei Wang, ... Peng Yang
Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics
Qiang Niu, Yu Liu, Yujing Zheng, Ziwei Tang, ... Ping Zhao
Chuchu Lin, Chenyi Huang, Zhaoqing Shi, Meitong Ou, ... Lin Mei
Spatio-temporal delivery of both intra- and extracellular toll-like receptor agonists for enhancing antigen-specific immune responses
Nannan Wang, Yueyue Zuo, Shengjie Wu, Chenlu Huang, ... Dunwan Zhu
Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors
Yuling Mao, Xiudan Wang, Caishun Chen, Qinfu Zhao, ... Siling Wang
Highlight
SMIP-30, a potent and selective PPM1A inhibitor with potential to treat tuberculosis
Shujing Xu, Xinyong Liu, Peng Zhan
Commentary
Acute psychological stress redistributed leukocytes via distinct brain circuits
Yan-Ping Wu, Rong-Rong He
