Acta Pharmaceutica Sinica B Vol. 15, Issue 7 Released

https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/7

Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.

APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.

Articles of interest in this issue include:

Trends in intestinal aging: From underlying mechanisms to therapeutic strategies by Yajun Wang, Xueni Zhang, Mengli Qing and colleagues, ( https://doi.org/10.1016/j.apsb.2025.05.011 ). Anti-intestinal aging can be used as an important strategy for reducing frailty and promoting longevity. This review summarizes the latest advances in the mechanisms and therapeutic strategies of intestinal aging.

Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells by Yuquan Tao, Yinuo Ma, Limei Gu and colleagues, ( https://doi.org/10.1016/j.apsb.2025.05.013 ). Single-cell RNA sequencing in Apc^Min/+ mice and clinical specimens demonstrates that Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by regulating TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells.

CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury by Yong Chen, Xue Yuan, Wei Yan and colleagues, ( https://doi.org/10.1016/j.apsb.2025.05.003 ). RP20, as a promising preclinical RIPK2 inhibitor candidate, exhibited excellent kinase selectivity, perfect oral pharmacokinetics, and high safety. It exhibited better therapeutic effects than N-acetylcysteine and GSK2983559 in APAP-induced ALI model. This represents the inaugural deployment of RIPK2 inhibitors in the treatment of ALI, thereby offering a novel therapeutic avenue for clinical application.

Other articles include:

Reviews

Artificial intelligence and anti-cancer drugs' response

Xinrui Long, Kai Sun, Sicen Lai, Yuancheng Liu, ... Kai Huang

Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis

Yufei Hui, Xue Jiao, Li Yang, Dejin Lu, ... Minjie Wei

Immune organoid for cancer immunotherapy

Xiao-He Wang, Wu-Yin Wang, Zhi-Jun Sun

Unraveling the therapeutic landscape of approved non-peptide macrocycles

Zhonghua Li, Zhenqiang Zhang, Bin Yu

Extracellular vesicles as biomarkers and drug delivery systems for tumor

Xue Wang, Wenjing Chen, Wei Zeng, Kuanhan Feng, ... Ruoning Wang

Nanomedicine-induced pyroptosis for anti-tumor immunotherapy: Mechanism analysis and application prospects

Yuelin Huang, Chunting Wang, Yanhong Chen, Dengbin Wang, Defan Yao

Advances in research on biomaterials and stem cell/exosome-based strategies in the treatment of traumatic brain injury

Wenya Chi, Yingying He, Shuisheng Chen, Lingyi Guo, ... Yuan Yu

Original articles

Enzyme-independent functions of HDAC3 in the adult heart

Sichong Qian, Chen Zhang, Wenbo Li, Shiyang Song, ... Zheng Sun

Antisense oligonucleotides targeting IRF4 alleviate psoriasis

Yanxia Yu, Yirui Wang, Weiwei Chen, Chang Zhang, ... Liangdan Sun

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

Xiaohui Zhang, Xinyu Tang, Ting Gao, Yuanfang Guo, ... Junlian Gu

RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis

Lijun Cai, Meimei Yin, Shuangzhou Peng, Fen Lin, ... Xiao-Kun Zhang

Linagliptin synergizes with cPLA2 inhibition to enhance temozolomide efficacy by interrupting DPP4-mediated EGFR stabilization in glioma

Dongyuan Su, Biao Hong, Shixue Yang, Jixing Zhao, ... Chunsheng Kang

Discovery of Yersinia LcrV as a novel biased agonist of formyl peptide receptor 1 to bi-directionally modulate intracellular kinases in triple-negative breast cancer

Yunjun Ge, Huiwen Guan, Ting Li, Jie Wang, ... Guosheng Wu

Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection

Xiu Liu, Li Zhao, Deshen Liu, Lingna Zhao, ... Shaoyi Zheng

Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway

Xian-Jia Li, Ke-Xin Huang, Ke-Xin Wang, Ru Liu, ... Hai-Ming Guo

Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture

Hui Chen, Hanqi Zhang, Chao Niu, Bianlin Wang, ... Haji Akber Aisa

Autonomous drug delivery and scar microenvironment remodeling using micromotor-driven microneedles for hypertrophic scars therapy

Ting Wen, Yanping Fu, Xiangting Yi, Ying Sun, ... Guilan Quan

Engineered platelet-derived exosomal spheres for enhanced tumor penetration and extended circulation in melanoma immunotherapy

Jian Zhao, Xinyan Lv, Qi Lu, Kaiyuan Wang, ... Jin Sun

A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers

Jialing Cheng, Zhiyang Chen, Demin Lin, Yanfang Yang, ... Yuling Liu

High intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming

Xuejing Li, Jiayi Wu, Ruizhe Xu, Xifeng Qin, ... Zhiqing Pang

Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors

Changyong Guo, Shipeng He, Huaxing Shen, Wei Cong, ... Honggang Hu

Letter to the Editor

Non-blocking anti-PD-L1 nanobody conjugated to TLR7 agonist mediates macrophage/NK cell-associated antitumor effects

Chao Hu, Chen Chen, Xiaolu Yu, Zhiying Li, ... Likun Gong

Highlights

Reshaping antivenom therapy: A triple-synergy strategy featuring broadly neutralizing antibodies and a small-molecule PLA₂ inhibitor

Yangyihua Zhou, Ning Shi, Xiang Gao, Longlong Luo

Sympathetic nerve activity in obesity-associated insulin resistance

Shuchou Xia, Huili Wu, Jianping Ye

Editorials

Traditional Chinese medicine in the early prevention of colorectal cancer from the perspective of tumor microenvironment

Huan Tang, Jigang Wang

A transformer-based strategy to develop RP20 as a potent RIPK2 inhibitor for acetaminophen-induced acute liver injury

Liang Ouyang