Researchers at Moorfields Eye Hospital and UCL Institute of Ophthalmology have developed an artificial intelligence (AI) system that has the potential to not only identify sight-threatening eye diseases but also predict general health, including heart attacks, stroke, and Parkinson's disease.
RETFound, one of the first AI foundation models in healthcare, and the first in ophthalmology, was developed using millions of eye scans from the NHS. The research team are making the system open-source: freely available to use by any institution worldwide, to act as a cornerstone for global efforts to detect and treat blindness using AI. This work has been published in Nature today.
Progress in AI continues to accelerate at a dizzying pace, with excitement being generated by the development of 'foundation' models such as ChatGPT. A foundation model describes a very large, complex AI system, trained on huge amounts of unlabelled data, which can be fine-tuned for a diverse range of subsequent tasks. RETFound consistently outperforms existing state-of-the-art AI systems across a range of complex clinical tasks, and even more importantly, it addresses a significant shortcoming of many current AI systems by working well in diverse populations, and in patients with rare disease.
Senior author Professor Pearse Keane (UCL Institute of Ophthalmology and Moorfields Eye Hospital) said: "This is another big step towards using AI to reinvent the eye examination for the 21st century, both in the UK and globally. We show several exemplar conditions where RETFound can be used, but it has the potential to be developed further for hundreds of other sight-threatening eye diseases that we haven't yet explored.
"If the UK can combine high quality clinical data from the NHS, with top computer science expertise from its universities, it has the true potential to be a world leader in AI-enabled healthcare. We believe that our work provides a template for how this can be done."
AI foundation models have been called "a transformative technology" by the UK government in a report published earlier this year, and have come under the spotlight with the launch in November 2022 of ChatGPT, a foundation model trained using vast quantities of text data to develop a versatile language tool. Taking a comparable approach with eye images in a world-first, RETFound has been trained on millions of retinal scans to create a model that can be adapted for potentially limitless uses.
