Dual antiplatelet therapy after heart bypass surgery is not more effective than aspirin alone - and it increases the risk of excessive bleeding. This has now been shown in a study of 2,201 patients at 22 Nordic heart surgery units.
The study was published on Monday in the prominent medical journal The New England Journal of Medicine at the same time that the results are being presented in Madrid at this year's ESC Congress, the leading international cardiology congress.
The lead investigator is Anders Jeppsson, professor in cardiothoracic surgery at the University of Gothenburg and senior consultant at Sahlgrenska University Hospital, as well as initiator and chair of the steering committee of the TACSI trial.
Risk reduction unclear until now
The TACSI study compares two different antiplatelet (blood thinning) therapies after heart bypass surgery for acute coronary heart disease. On the one hand single antiplatelet therapy with acetylsalicylic acid (Aspirin) alone, and on the other hand dual antiplatelet therapy with aspirin and ticagrelor (Brilique). Dual antiplatelet therapy is currently recommended for these patients in international guidelines.
It is unequivocal that this patient group needs antiplatelet therapy. However, until now it has been unclear whether dual therapy after surgery further reduces the risks of death and cardiovascular complications after the operation.
The 2,201 patients included in the study were randomly assigned to receive either ticagrelor and aspirin (1,104 patients) or aspirin alone (1,097 patients). The average age of the participants was 66 years and the proportion of women was 14.4 percent. The follow-up period was 12 months after surgery.
The results show no difference between the groups within the study's primary focus: a composite measure of the risks of dying, having a heart attack or stroke, or needing another coronary intervention. The proportion affected within one year was just under 5 percent for both groups.
No support for dual therapy
However, the researchers found that the groups did differ if excessive bleeding was also included. When including excessive bleeding, the proportion affected was 9.1 percent in the group receiving both ticagrelor and aspirin and 6.4 percent in the group receiving aspirin alone. Excessive bleeding was seen in 4.9 percent of patients on dual therapy, as compared to 2.0 percent in the other patient group.
Anders Jeppsson notes that while the patients need to be followed up for more than one year, we can still draw some conclusions:
"Our 12-month data do not support the use of dual therapy over aspirin alone in patients with acute coronary syndrome who have undergone heart bypass surgery. We did not observe any improvement in serious cardiovascular events, but a higher risk of excessive bleeding in the dual antiplatelet therapy group," he says.
Study: Ticagrelor and Aspirin or Aspirin Alone after Coronary Surgery for Acute Coronary Syndrome
