University of Tübingen researchers reverse the evolution of a class of antibiotics to gain in-sights for the development of new drugs. Illustration: Anna Voigtländer.
University of Tübingen/CMFI
To understand how the ancestor of today's glycopeptide antibiotics - such as vancomycin, ristomycin and teicoplanin - might have looked like, the researchers used a combination of bioinformatics, genetic and biochemical methods to bring the putative ancestral antibiotic "paleomycin" or "Frankenstein molecule" to life. Illustration Leon Kokkoliadis, Libera Lo Presti and Johanna Stegmann with BioRender.
Publication:
Mathias Hansen, Martina Adamek, Dumitrita Iftime, Daniel Petras, Frauke Schuseil, Stephanie Grond, Evi Stegmann, Max Cryle and Nadine Ziemert: Resurrecting Ancestral Antibiotics: Unveiling the Origins of Modern Lipid II Targeting Glycopeptides. Nature Communications, https://doi.org/10.1038/s41467-023-43451-4
University of Tübingen/CMFI
University of Tübingen researchers reverse the evolution of a class of antibiotics to gain in-sights for the development of new drugs. Illustration: Anna Voigtländer.
University of Tübingen/CMFI
To understand how the ancestor of today's glycopeptide antibiotics - such as vancomycin, ristomycin and teicoplanin - might have looked like, the researchers used a combination of bioinformatics, genetic and biochemical methods to bring the putative ancestral antibiotic "paleomycin" or "Frankenstein molecule" to life. Illustration Leon Kokkoliadis, Libera Lo Presti and Johanna Stegmann with BioRender.
Publication:
Mathias Hansen, Martina Adamek, Dumitrita Iftime, Daniel Petras, Frauke Schuseil, Stephanie Grond, Evi Stegmann, Max Cryle and Nadine Ziemert: Resurrecting Ancestral Antibiotics: Unveiling the Origins of Modern Lipid II Targeting Glycopeptides. Nature Communications, https://doi.org/10.1038/s41467-023-43451-4
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