Uncover Chemo-resistance Mechanism in Glioma Patients

An international research team co-led by the Hong Kong University of Science and Technology (HKUST), Beijing Neurosurgical Institute, and the Spanish National Cancer Research Center (CNIO) has discovered a mechanism that explains why patients of gliomas – a common and aggressive type of brain tumors, would develop chemo-resistance, potentially allowing early identification of drug-resistant brain cancer patients.

At present, the main treatment for glioma is a combination of surgery, radiotherapy and the chemotherapy agent temozolomide (TMZ). This type of treatment can usually prolong patients’ overall survival time. However, most of them would suffer a relapse and some would become resistant to TMZ.

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