Extending a motorized brace approach to take the load off arthritic knees, a U-M research team shifts from boosting strength to reducing joint contact forces
Key takeaways
- Preliminary testing suggests that exoskeletons built from orthotic braces and drone-style motors could relieve arthritis pain
- An estimated 14 million people in the U.S. have symptoms from osteoarthritis in the knees
- The study is led by University of Michigan Engineering in collaboration with Michigan Medicine and funded by the National Institutes of Health
Building on the success of projects to boost strength by adding motors to conventional knee, hip and ankle braces, a University of Michigan team is exploring how well this approach could work for relieving knee pain from osteoarthritis.
"This could create an entirely new class of orthotic interventions that don't exist today, which could potentially delay surgery or spare people from having to undergo it," said Robert Gregg, U-M professor of robotics and leader of the project funded with $2 million from the National Institutes of Health.
In earlier work, exoskeletons, or exos, developed by Gregg's team reduced the effort expended by study participants by:
- 14.5% in quadriceps effort with knee exos
- 19.1% in lower ankle torque with ankle exos
- 25% in work done by the hip with hip exos
"We ran a pilot study with four people with knee osteoarthritis. They all experienced pain reduction," Gregg said. "If you reduce peak muscle forces at the joint, you're reducing the peak loads of the contractile muscles that pull the joint together. You reduce that peak, and you reduce arthritic pain."
Reducing contact forces inside knee joints
Before inviting study participants to the lab, the researchers will optimize their exoskeletons for arthritis pain reduction. Gregg's team is very experienced at modeling muscle effort and joint torque, but they have not previously gone into the details of what is happening inside the joints.
Now, they will dig into musculoskeletal models to quantify how exo assistance reduces the bone-on-bone contact forces-and therefore the pain-inside arthritic joints. They will use this information to adapt the exo control algorithm to reduce contact forces rather than just muscle effort, and ultimately assess the effects on participants' self-reported pain across a variety of activities.
The control algorithm will be based on the "energy shaping" approach championed by Gregg's group, which contributed to the earlier successes with brace-based exos. Older control strategies often rely on guessing what the user is trying to do, such as walking up stairs or sitting down in a chair. Instead, the energy-shaping algorithm looks at the user's current motion and predicts how much force is needed in the next fraction of a second. The predictions come from models of human movement made with motion capture data and physics.
The design of the exos themselves will be very similar to the previous effort to boost strength. The team, including co-investigator Elliott Rouse, U-M associate professor of robotics, uses "pancake" motors popularized by the drone industry. The key advantage of these motors is high torque at low speeds, providing a force similar to human joints.
Earlier motors that were small enough to mount on knee braces needed more gears to provide higher torque. Gears are louder and harder to drive backward, resulting in exos that are stiff and noisy, similar in volume to a household drill. Pancake motors provide both the power and smooth operation needed for compatibility with human motion while being nearly silent.
Clinical trial with participants who have arthritis
Co-investigators Edward Wojtys, the William S. Smith Legacy Professor of Orthopaedic Surgery, and Damon Bagley-Ayres, a certified prosthetist and orthotist for Michigan Medicine, will recruit participants with osteoarthritis and support the clinical trial. Steven Harte, an associate professor of anesthesiology and internal medicine at Michigan Medicine, will support the rigorous assessment of pain.
While this study is a lab trial, Gregg hopes to eventually send exos home with users to see whether they reduce the vicious cycle of muscle wasting that accompanies osteoarthritis. Because exoskeletons make each step easier, muscle atrophy could get worse if users aren't moving more. The team is betting that if exo users can move with less pain, they will move more often, and increasing cumulative activity levels could strengthen the muscles of exo users.
