In 2021 Acta Pharmaceutica Sinica B (APSB) is celebrating its 10th anniversary. The journal was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Featured papers in this issue are:
Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer by Yi Qian, Meimei Zhao, Qinghua Han, Jingkang Wang, Lixi Liao, Heng Yang, Dan Liu, Pengfei Tu, Hong Liang and Kewu Zeng (https://doi.org/10.1016/j.apsb.2021.01.011). Natural-derived small-molecule J13 restrained the interaction between myosin-9 (MYH9) and actin molecular motor via prompting heat-shock protein A9 (HSPA9) attached to MYH9, resulting in excessive mitochondrial fission with implications for human cancer therapy.
A novel PGAM5 inhibitor LFHP-1c protects blood–brain barrier integrity in ischemic stroke by authors Chenglong Gao, Yazhou Xu, Zhuangzhuang Liang, Yunjie Wang, Qinghong Shang, Shengbin Zhang, Cunfang Wang, Mingmin Ni, Dalei Wu, Zhangjian Huang and Tao Pang (https://doi.org/10.1016/j.apsb.2021.01.008). LFHP-1c directly binding to PGAM5 inhibits PGAM5 enzyme activity and impairs PGAM5 interaction with NRF2, promoting NRF2 transcription activity to protect against blood–brain barrier disruption and ischemic brain injury.
AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases by Qingqing Dai, Yuhang Yan, Xiangli Ning, Gen Li, Junlin Yua, Ji Deng, Lingling Yang and Guo-Bo Li (https://doi.org/10.1016/j.apsb.2021.01.018). The authors of this paper describe AncPhore, a versatile tool for drug discovery, which is characterized by pharmacophore feature analysis and anchor pharmacophore (i.e., most important pharmacophore features) steered molecular fitting and virtual screening.
Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder by authors Lulu Pang, Siqing Zhu, Jinqiu Ma, Lin Zhu, Yijing Liu, Ge Ou, Ruiteng Li, Yaxin Wang, Yi Liang, Xu Jin, Lina Du and Yiguang Jin (https://doi.org/10.1016/j.apsb.2021.01.014). Nasal delivery of cannabidiol inclusion complex temperature-sensitive hydrogels could effectively target to brains for the treatment of mice with post-traumatic stress disorder (PTSD), which is a novel promising option for the clinical treatment of PTSD.
Other articles published in the issue include:
Reviews
3D organoids derived from the small intestine: An emerging tool for drug transport research
Yuanjin Zhang, Shengbo Huang, Weiguo Zhong, Wenxia Chen et al.
https://doi.org/10.1016/j.apsb.2020.12.002
Natural compounds modulate the autophagy with potential implication of stroke
Anil Ahsan, Mengru Liu, Yanrong Zheng, Wenping Yan et al.
https://doi.org/10.1016/j.apsb.2020.10.018
Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects
Javad Masoumi, Abdollah Jafarzadeh, Jalal Abdolalizadeh, Haroon Khan et al.
https://doi.org/10.1016/j.apsb.2020.12.015
The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review
Niranjan Das, Siddhartha Kumar Mishra, Anusha Bishayee, Eunüs S. Ali, Anupam Bishayee
https://doi.org/10.1016/j.apsb.2020.10.012
Recent advances in nanomedicines for the treatment of ischemic stroke
Chao Li, Tao Sun, Chen Jiang
https://doi.org/10.1016/j.apsb.2020.11.019
The influence of the gut microbiota on the bioavailability of oral drugs
Xintong Zhang, Ying Han, Wei Huang, Mingji Jin, Zhonggao Gao
https://doi.org/10.1016/j.apsb.2020.09.013
Ginsenosides in Panax genus and their biosynthesis
Maoqi Hou, Rufeng Wang, Shujuan Zhao, Zhengtao Wang
https://doi.org/10.1016/j.apsb.2020.12.017
Original articles
Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats
Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang et al.
https://doi.org/10.1016/j.apsb.2021.01.015
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
Xu Wu, Chun Yin, Jiang Ma, Stella Chai et al.
https://doi.org/10.1016/j.apsb.2020.12.021
Protective effects of VMY-2-95 on corticosterone-induced injuries in mice and cellular models
Ziru Yu, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du
https://doi.org/10.1016/j.apsb.2021.03.002
Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle
Qingfeng Yu, Chengjie Wu, Yeda Chen, Bingsheng Li et al.
https://doi.org/10.1016/j.apsb.2021.01.005
Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent
Yuxi Wang, Jian Gao, Song Zhao, Yan Song et al.
https://doi.org/10.1016/j.apsb.2020.11.004
Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy
Ziyan Zhang, Qiaojuan Liu, Jizhou Tan, Xiaoxia Zhan et al.
https://doi.org/10.1016/j.apsb.2021.04.002
Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence
Yingying Zhang, Tiange Wang, Yu Tian, Chaonan Zhang et al.
https://doi.org/10.1016/j.apsb.2021.03.035
The cellular immunotherapy of integrated photothermal anti-oxidation Pd–Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis
Chuping Zheng, Aiping Wu, Xinyun Zhai, Hong Ji et al.
https://doi.org/10.1016/j.apsb.2021.02.021
Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy
Ling Yu, Zhenjie Wang, Zhuomao Mo, Binhua Zou et al.
https://doi.org/10.1016/j.apsb.2021.02.001
In situ triggering antitumor efficacy of alcohol-abuse drug disulfiram through Cu-based metal-organic framework nanoparticles
Lin Hou, Yanlong Liu, Wei Liu, Mervat Balash et al.
https://doi.org/10.1016/j.apsb.2021.01.013
Pure redox-sensitive paclitaxel–maleimide prodrug nanoparticles: Endogenous albumin-induced size switching and improved antitumor efficiency
Xinyu Lou, Dong Zhang, Hao Ling, Zhonggui He et al.
https://doi.org/10.1016/j.apsb.2020.12.001
Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction
Bozhao Li, Jingyan Wei, Chunzhi Di, Zefang Lu et al.
https://doi.org/10.1016/j.apsb.2020.11.014
Enzyme-instructed hybrid nanogel/nanofiber oligopeptide hydrogel for localized protein delivery
Tianyue Jiang, Yudi Ma, Xiao Xu, Qingchun Ji et al.
https://doi.org/10.1016/j.apsb.2020.11.010
The chromosome-level reference genome assembly for Dendrobium officinale and its utility of functional genomics research and molecular breeding study
Zhitao Niu, Fei Zhu, Yajuan Fan, Chao Li et al.
https://doi.org/10.1016/j.apsb.2021.01.019
