Mass General Brigham investigators have developed a robust new artificial intelligence (AI) foundation model that is capable of analyzing brain MRI datasets to perform numerous medical tasks, including identifying brain age, predicting dementia risk, detecting brain tumor mutations and predicting brain cancer survival. The tool. known as BrainIAC, outperformed other, more task-specific AI models and was especially efficient when limited training data were available. Results are published in Nature Neuroscience.
"BrainIAC has the potential to accelerate biomarker discovery, enhance diagnostic tools and speed the adoption of AI in clinical practice," said corresponding author Benjamin Kann, MD, of the Artificial Intelligence in Medicine (AIM) Program at Mass General Brigham. "Integrating BrainIAC into imaging protocols could help clinicians better personalize and improve patient care."
Despite recent advances in medical AI approaches, there is a lack of publicly available models that focus on broad, brain MRI analysis. Most conventional frameworks perform specific tasks and require extensive training with large, annotated datasets that can be hard to obtain. Furthermore, brain MRI images from different institutions can vary in appearance and based on their intended applications (such as in neurology versus oncology care), making it challenging for AI frameworks to learn similar information from them.
To address these limitations, the research team designed a brain imaging adaptive core, or BrainIAC. The tool uses a method called self-supervised learning to identify inherent features from unlabeled datasets, which can then be adapted to a range of applications. After pretraining the framework on multiple brain MRI imaging datasets, the researchers validated its performance on 48,965 diverse brain MRI scans across seven distinct tasks of varying clinical complexity.
They found that BrainIAC could successfully generalize its learnings across healthy and abnormal images and subsequently apply them to both relatively straightforward tasks, such as classifying MRI scan types, and very challenging tasks, such as detecting brain tumor mutation types. The model also outperformed three more conventional, task-specific AI frameworks at these applications and others.
The authors note that BrainIAC was especially good at predicting outcomes when training data was scarce or task complexity was high, suggesting that the model could adapt well to real-world settings where annotated medical datasets are not always readily available. Further research is needed to test this framework on additional brain imaging methods and larger datasets.
Authorship: In addition to Kann, Mass General Brigham authors include Divyanshu Tak, Biniam A. Garomsa, Anna Zapaishchykova, Tafadzwa L. Chaunzwa, Juan Carlos Climent Pardo, Zezhong Ye, John Zielke, Yashwanth Ravipati, Suraj Pai, Omar Arnaout, Hugo JWL Aerts, and Raymond Y. Huang. Additional authors include Sri Vajapeyam, Maryam Mahootiha, Mitchell Parker, Luke R. G. Pike, Ceilidh Smith, Ariana M. Familiar, Kevin X. Liu, Sanjay Prabhu, Pratiti Bandopadhayay, Ali Nabavizadeh, Sabine Mueller, and Tina Y. Poussaint.
Disclosures: None.
Funding: This study was supported in part by the National Institute of Health/ the National Cancer Institute (NIH/NCI) (U54 CA274516 and P50 CA165962), and Botha-Chan Low Grade Glioma Consortium. Authors acknowledge the Children's Brain Tumor Network (CBTN) for the imaging and clinical data access, and ASCO Conquer Cancer Foundation: 2022A013157 Radiation Oncology Institute: ROI2022-9151.
Paper cited: Tak D et al. "A foundation model for generalized brain MRI analysis" Nature Neuroscience DOI: 10.1038/s41593-026-02202-6
