In about 5–10% of colorectal cancer patients, hereditary factors play a role, with higher percentages among younger patients. Research from Radboud university medical center and university hospital Bonn (UKB) in collaboration with researchers from Munich and Barcelona, shows that DNA analysis of colorectal polyps provides important additional information on the development of these polyps and colorectal cancer. This DNA analysis leads to better diagnostics and treatment and offers patients and their family members greater clarity. The results have now been published in Gastroenterology.
Colorectal cancer is one of the most common cancers in the Western world (WHO fact sheet). It is estimated that hereditary factors play a role in about 5–10% of these cases, with a higher prevalence of hereditary factors in younger patients. A large number of colorectal polyps are considered potential precursors to cancer: at least 10 polyps in people under 60 and more than 20 in those under 70. These individuals can undergo genetic testing through blood DNA analysis. In about one-quarter of cases, a genetic cause is identified. These patients and the mutation carriers among their relatives qualify for regular screenings to detect and treat colorectal cancer at an early stage.
