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A single episode of delirium - a state of confusion and agitation - in hospitalised older adults is a significant risk factor for other serious health complications including fractures, stroke and sepsis, a University of Queensland study has found.
Key points
- A single episode of confusion and agitation in hospital is a significant risk factor for other serious health complications.
- Data was analysed from 30,000 patients and hospital records over 26 years to assess long-term clinical consequences of delirium.
- The study showed a persistently elevated risk of adverse health outcomes even after the delirium episode subsides.
Delirium is often triggered by infection, surgery, pain, dehydration or medication, which affects up to 1 in 4 older adults during a hospital stay. However, many of its long‑term health impacts have not been fully understood.
In a large-scale study, Dr David Ward from UQ's Centre for Health Services Research said researchers analysed data from nearly 30,000 patients and hospital records over a period of up to 26 years to assess long-term clinical consequences of in-hospital delirium.
"We found delirium was associated with a higher risk of 12 adverse outcomes, independent of frailty and pre-existing dementia, which shows it is a warning of longer-term vulnerability," Dr Ward said.
"An episode of delirium in hospital doubled the risk of falls and urinary incontinence, and there was a 50 to 70 per cent increased risk of pneumonia, faecal incontinence, fractures, stroke, hip fracture, sepsis, acute kidney injury, and pressure injury.
"There was also a 20 to 30 per cent higher risk for gastrointestinal bleeding and heart failure.
"These are very strong associations that highlight delirium as a red flag for multisystem vulnerability, and we hope these findings will help guide follow-up care and prevention strategies."
Dr Ward said research showed up to half of all delirium cases that develop in hospital could be prevented through better care practices.
Lead author Dr Markus Haapanen from the University of Helsinki, who undertook a fellowship at UQ for this study, said episodes of delirium were often thought of as a short-lived complication, but the study showed a persistently elevated risk of adverse health outcomes even after the episode subsides.
"Identifying and managing delirium while patients are in hospital is often the focus of care, but these results suggest a need to extend treatment and care after a patient is discharged," Dr Haapanen said.
"Delirium prevention, treatments and structured follow-up for patients recovering from delirium represent opportunities for improving care and outcomes beyond hospitalisation.
"This research also opens the door for future studies to measure longer-term health outcomes following a delirium episode."
The study used data from 30,000 UK Biobank participants.
The research was published in The Lancet Healthy Longevity.
Collaboration and acknowledgements
The study was funded by Sigrid Jusélius Foundation, the Osk Huttunen Foundation, the Biomedicum Helsinki Foundation, and Finska Läkaresällskapet with contributions from the Australian Frailty Network, the University of Helsinki, the Royal Brisbane and Women's Hospital, Queensland University of Technology and Dalhousie University.
