People with diabetes, depression improve with TLC


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More than 70 percent in group receiving the integrated approach had improvements in diabetes and depression.

People with chronic diseases, such as diabetes, are more likely to experience depression and have poorer outcomes when depression occurs. A study published today in JAMA found that team-based care in diabetes clinics in India improved both depression and diabetes outcomes.

Researchers from Emory University, University of Washington School of Medicine, and their colleagues in India compared a collaborative care model with usual care in 404 patients with diabetes and moderate-to-severe depressive symptoms. More than 70 percent in the group receiving the integrated approach had improvements in diabetes and depression.

The results of the In the INDEPENDENT (Integrating Depression and Diabetes Treatment) study were published in JAMA Aug. 18.

“Too often, mental health is overlooked due to fragmented care, stigma of psychiatric illnesses, and shortages of mental health professions,” said first author Mohammed Ali, vice chair of family and preventive medicine at Emory University.

Ali said that depression worsens patients’ likelihood of managing their diabetes well. Poorly controlled diabetes can result in higher risk of heart attacks and other diabetes complications and greater mortality.

Globally, there is a shortage of psychiatrists to address the mental health needs of patients with diabetes. Although there are effective treatments for depression, between 76% and 85% of people in low- and middle-income countries receive no treatment for this disorder, said researchers.

The model in the study was adapted from a collaborative care model developed by the late Dr. Wayne Katon, vice chair of psychiatry and behavioral sciences at the University of Washington School of Medicine. Katon developed an influential research program on the effects of depression on physical health.

This was the first time the model was implemented outside of the United States, said co-author Lydia Chwastiak, one of three principal investigators on the study and a professor of psychiatry and behavioral sciences at the University of Washington School of Medicine. The work to culturally adapt the model to India was led by Deepa Rao, professor of global health at the University of Washington.

“The real power of this model is bringing mental health care to people who cannot access it elsewhere,” said Chwastiak. “What is most exciting is that this model might be an effective strategy for addressing severe health workforce shortages.”

Chwastiak led training of 10 nutritionists who worked in four diabetes clinics to be patient-care managers. The care managers worked with patients, their family members and doctor and a consulting psychiatrist on an individualized treatment plans. The patient care manager advocated for the patient and supported them to manage their illness more effectively.

“The relationship with the patient care manager was so powerful,” said Chwastiak. “The patients were very attached to them.”

Senior author Dr. Viswanathan Mohan, chairman of Dr. Mohan’s Diabetes Specialties Centre and director of Madras Diabetes Research Foundation in India, called the findings impressive.

“This was the first study reporting on whether a one-year integrated, collaborative care model has sustainable effects at two years,” said Mohan. “This low-cost model produced impressive results both in improving depression as well as in several metabolic parameters and can be useful in other settings and countries.”

Contributing authors also included K.M. Venkat Narayan, and Shivani Patel from Emory University. The study was funded by the National Institute of Mental Health Grant No: R01MH100390-01.

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