A new study identified new protein targets and drug candidates, including opportunities to repurpose existing drugs. Six key proteins were highlighted as potentially providing new insights and supporting future treatment development for progressive multiple sclerosis.
"Using a multi-omics approach, we prioritized 48 genetically supported proteins, identified 14 proteins with therapeutic potential, and highlighted 13 non-MS drugs with potential for repurposing. Through further validation, we identified six key proteins that may provide new biological insight into progressive multiple sclerosis and support future therapeutic exploration", says Yuan Jiang , affiliated with the Department of Medicine , Huddinge, and the Department of Clinical Neuroscience in Solna, and the lead author of the study.
These findings may be of interest to professionals in neurology, neuroimmunology, genetics, drug development, and precision medicine, especially given the urgent need for better treatments targeting disease progression and neurodegeneration in multiple sclerosis.
The study is published in Journal of Neuroinflammation.
Link to the study:
" Multi-omics integration provides biological insight and prioritizes potential drug targets in multiple sclerosis progression ", Yuan Jiang, Jinyu Xiao, Ingrid Kockum, Pernilla Stridh, Qianwen Liu, Tomas Olsson, Lars Alfredsson & Xia Jiang, Journal of Neuroinflammation, online 2 juni 2026, doi: org/10.1186/s12974-026-03895-z.
