https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/12
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:
Graph neural networks driven acceleration in drug discovery by Rui Wang and Chunlin Zhuang ( https://doi.org/10.1016/j.apsb.2025.10.011 ). GNNs are revolutionizing drug design by accurately modeling molecular structures and interactions. They enhance property prediction, drug repurposing, toxicity assessment, and novel molecule design, accelerating discovery while reducing costs and failures.
Artificial intelligence for radiopharmaceutical and molecular imaging by Jinping Tao, Ling Liang, Siqi Hao and colleagues ( https://doi.org/10.1016/j.apsb.2025.09.039 ). Artificial intelligence (AI) drives revolutionary changes in nuclear medicine by advancing radiopharmaceuticals (target/ligand/delivery), boosting molecular imaging, and accelerating clinical translation.
Generation and applications of an expandable and mature hiPSC-derived liver organoid by Sen Liu, Ze Wang, Liuyang Zhu and colleagues ( https://doi.org/10.1016/j.apsb.2025.09.029 ). This study induced liver endoderm formation with SB431542 and BMP4 to generate liver organoids that possess both amplification and maturation capabilities within the liver.
Rational engineering of degradation tail-driven CELMoD–antibody conjugates for precision malignancy therapy by Yu Guo, Yi Song, Hanlin Wang and colleagues ( https://doi.org/10.1016/j.apsb.2025.09.009 ). Rationally engineered CELMoD–antibody conjugates (Dara-VA-I034) enable complete tumor eradication via CD38-targeted degradation with a unique positive-feedback loop, outperforming auristatin-based ADCs in efficacy and safety.
Other articles include:
Reviews
Jiawei Song, Lu Ye, Wei-Qun Ding, Huaijin Qiao, ... Shuyu Zhang
Emerging epigenetic modifications in renal fibrosis: From mechanisms to treatments
Xiaoguo Suo, Qinglin Ge, Lijin Peng, Qi Zhu, ... Xiaoming Meng
m6A readers: Promising therapeutic targets in cancer treatment
Xinyue Wang, Xuetao Chen, Shuai Wen, Yi Mou, ... Zhengyu Jiang
Recent advances in engineering nano/microrobots for tumor treatment
Xifeng Qin, Ruizhe Xu, Jiayi Wu, Yue Liu, ... Zhiqing Pang
Site-specific PEGylation of proteins: Insights into structural and functional changes
Ming Ma, Jinwei Di, Chengcai Wang, Yanwei Xie, ... Jing Gao
Wanzhuo He, Tian Xu, Miao Wang, Ni Ni, ... Xianqun Fan
Lu Gan, Xincheng Lin, Ziqiao Zhong, Yichun Zheng, ... Wenhao Wang
Progress in peptide and protein therapeutics: Challenges and strategies
Mengyang Liu, Darren Svirskis, Thomas Proft, Jacelyn Loh, ... Jingyuan Wen
Original articles
Ju Hwan Yang, Sumin Sohn, Sunghyun Kim, Jieun Kim, ... Eun Sang Choe
Haonan Li, Daimin Luo, Chuangnan Qiu, Xianzhi Wei, ... Xianxing Jiang
Lipeng Tang, Guanzhuo Li, Jiameng Chang, Haiyan Xian, ... Guangjuan Zheng
Wei Xu, Minmin Shen, Junjie Ma, Chuanlin Peng, ... Bo Zhang
Jing Feng, Yingying Hu, Xiuxiu Sun, Yutong Hao, ... Xin Liu
IGF2BP1 positively regulates CircOGDH accumulation in hypoxia induced stress granules
Xuanlin Su, Jiankun Zang, Yaping Wang, Shiqing Zhang, ... Dan Lu
Yuyi Zheng, Xiaotian Zhang, Xiaoxia Gu, Yongqi Li, ... Hucheng Zhu
Bo Huang, Emily Gregory-Lott, Bingbing X. Li, Timothy H. Tran, ... Jianfeng Cai
Zhiming Chen, Cheng Zhang, Hui Shen, Hongrui Xu, ... Yong Xu
Honglei Wang, Zibei Wu, Chen Gao, Wenhao Wang, ... Jintao Fu
Nan Wang, Lingling Wu, Yaya Su, Chi Zhang, ... Hailong Yuan
Yingying Xu, Jiajia Gui, Yunxiao Zhang, Simin Nan, ... Yao Fu
Jing Li, Hongbo Wu, Hanyue Li, Yue Zhang, ... Lin Mei
Guoqing Wang, Kai Wu, Zongliang Zhang, Yongdong Chen, ... Fang Lu
Yu Zhao, Danyang Zhang, Lin Meng, Siming Shan, ... Lingyi Kong
Ranran Yuan, Zhen Mu, Houqian Zhang, Yu Tian, ... Yanan Shi
Zeru Li, Huipeng Xu, Siwen Wang, Qin Nie, ... Li Wu
Jian Rong, Chunyu Zhao, Ahmad F. Chaudhary, Tim Ware, ... Steven H. Liang
Letter to the editor
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative
Yuanguang Chen, Yongqing Liu, Guanguan Li, Chao Peng, ... Xumu Zhang
Highlights
Neuroimmune circuit mediates apathy in cancer cachexia
Yongrui Hai, Renming Fan, Fangfang Qi, Minggao Zhao, Gaofei Wei
Bo Wang, Jiwei Zhang, Xinyong Liu, Peng Zhan
Commentaries
CELMoD–antibody conjugates unlock a CD38 feedback loop in multiple myeloma
Jian Jin
Edward Zhou
