An update from scientists from Pusan National University

Pusan National University

Epilepsy, a common neurological disorder associated with stigma, psychiatric comorbidities, and rising healthcare costs, affects approximately 50 million people globally. A common risk factor associated with the development of epilepsy and seizures is alcohol consumption.

Various studies have focused on how alcohol consumption leads to provoked seizures, commonly occurring due to alcohol withdrawal, or heavy alcohol intoxication. However, very few of these focus on the link between alcohol consumption and unprovoked seizures. One such study was a meta-analysis conducted in 2010, which analyzed six case-control studies and found that alcohol users were more prone to developing unprovoked seizures.

Interestingly, data from recent cohort studies contradict these findings, implying that there is no association between alcohol intake and epilepsy.

Now, using more accurate diagnostic methods and recent data, a team of scientists led by Professor Kyoung Nam Woo and including Professor Yun Hak Kim from Pusan National University, South Korea, conducted an updated meta-analysis to conclusively clarify the relationship between alcohol consumption and unprovoked seizures and epilepsy.

For this meta-analysis, which was made available online in the Drug and Alcohol Dependence journal on January 11, 2022, the team included a total of 8 studies, comprising 5 case-control studies and 3 cohort studies. Further, they conducted a cubic spline analysis on data extracted from these studies, to assess the dose-response relationship between alcohol intake and epilepsy.

The findings suggested that overall, alcohol drinkers were at a significantly higher risk of developing epilepsy, as compared to non-drinkers. A significant positive dose-response relationship was found upon analysis of case-control studies, implying that the risk of epilepsy increases with an increase in alcohol intake. These findings are consistent with previous meta-analyses.

An important finding was that cohort studies did not show a positive association between alcohol intake and epilepsy. In fact, 2 out of 3 cohort studies suggested that alcohol intake reduces the risk of epilepsy.

“Further large cohort studies of the general population are required to assert a definite causal relationship between alcohol consumption and epilepsy and to identify a potential threshold”, Prof. Kim suggests. Moreover, since cohort studies include more subjects, and are less prone to biases, they comparatively provide more accurate relationships between exposure and development of a disorder.

“An assessment of the risk of alcohol consumption in various clinical situations, such as types of CNS insult and the time relation of alcohol consumption with seizures, will be important for primary prevention. To increase the applicability to the general population, future studies should be conducted in which the potential confounders such as age, sex, and smoking have been adjusted”, says Prof. Woo, highlighting the long-term implications of this work.

Once clarity is achieved, assessment of the risk of alcohol consumption in different clinical situations will be an effective step for the prevention of epilepsy in the general population.

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Reference

DOI: https://doi.org/10.1016/j.drugalcdep.2022.109305

Authors: Kyoung Nam Woo1, Kihun Kim2, Dai Sik Ko3, Hyun Woo Kim1, Yun Hak Kim4,5

Affiliations:

1 Department of Neurology, Pusan National University, Republic of Korea

2 Department of Occupational and Environmental Medicine, Kosin University Gospel Hospital, Republic of Korea

3 Division of Vascular Surgery, Department of Surgery, Gachon University Gil Medical Center, Republic of Korea

4Department of Biomedical Informatics, School of Medicine, Pusan National University, Republic of Korea

5Department of Anatomy, School of Medicine, Pusan National University, Republic of Korea

About Pusan National University

Pusan National University, located in Busan, South Korea, was founded in 1946, and is now the no. 1 national university of South Korea in research and educational competency. The multi-campus university also has other smaller campuses in Yangsan, Miryang, and Ami. The university prides itself on the principles of truth, freedom, and service, and has approximately 30,000 students, 1200 professors, and 750 faculty members. The university is composed of 14 colleges (schools) and one independent division, with 103 departments in all.

Website: https://www.pusan.ac.kr/eng/Main.do

About the author

Prof. Yun Hak Kim is an Assistant Professor in the Department of Anatomy and the Department of Biomedical Informatics, Pusan National University, Yangsan in South Korea. His group focuses on developing and validating new biomarkers for several diseases using genomic big data, and was instrumental in developing the RNA and DNA sequencing analysis pipelines, which are essential techniques in bioinformatics.

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