Microfluidic chips hold great promise for unparalleled applications in pathogen detection and cancer diagnosis. Such devices often require nanoscale thin films for the filtering of liquid samples, as well as power devices or chemical stimulus that control its flow direction. However, many challenges still remain with most precedent mechanisms, including complicated fabrication processes, limitations of materials, and undesired damage on samples.
A research team, led by Professor Taesung Kim in the Department of Mechanical Engineering at UNIST presented the evaporation-driven transport-control of small molecules in gas-permeable and low-aspect ratio nanoslits, wherein both the diffusive and advective mass transports of solutes are affected by solvent evaporation through the nanoslit walls.
Unlike the existing method, the new technique has drawn considerable attention as a multi-functional core technology that enables the active and versatile control of small molecules, such as valving, concentrating, pumping, and filtering abilities on a chip, without damaging samples.
Figure 1. Global, evaporation-controlled, micro/nanofluidic device (GECMN) for transport control of small molecules. a) Schematic illustration of the GECMN consisting of two microchannels connected to the nanoslit. b) Diffusive mass transport of small molecules toward the drain channel is prohibited by the evaporation-driven advective flow from the drain toward the center of the nanoslit, making the small molecules accumulate in the dehydrated nanoslit. c) Accumulated small molecules transport toward the drain channel due to diffusion for the hydrated nanoslit.
In this study, the research team described the evaporation-driven transport control of small molecules along nanoslits. They experimentally investigated evaporation-driven mass transport using the polydimethylsiloxane (PDMS) system that not only exhibits a nanoporous property, but also enables the generation of an evaporation-driven flow. They performed numerical simulations to theoretically support the experimental results with the advection and diffusion model, thereby enabling description of the transport with the nondimensionalized diffusion coefficient and evaporation flux.
The researchers proved that the nanoslit can act as a valve and filter to enrich the sample or control the injection of the sample into the target chip by producing microfluidic chips that are connected by nanoslit. In particular, it was possible to concentrate samples (fluorescent molecule) at a concentration of 256 times the concentration of low molecules in the raw material chip within an hour.
Their findings have been published in the online version of Nature Communications on February 26, 2021. This study has been supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Ministry of Science and ICT (MSIT).
Journal Reference
Sangjin Seo, Dogyeong Ha, Taesung Kim, "Evaporation-driven transport-control of small molecules along nanoslits," Nat Commun., (2021).
