Fighting cancer with LIGHT

LIGHT accelerator
Model of the LIGHT accelerator, including treatment room.
(Image: AVO)

Cancer irradiation with hadron beams, a method to which CERN contributed by propelling carbon ion therapy of radioresistant tumours into the medical world some thirty years ago, has treated more than 300 000 patients to date. As collaborations and projects have mushroomed over the decades, new methods aimed at improving and democratising this type of cancer treatment have sprung to life. Among these methods, therapy with proton beams from circular accelerators stands out as a particularly effective treatment: protons can obliterate tumours, sparing the surrounding healthy tissues at higher rates than conventional electron or photon therapy. Unfortunately, present proton and ion therapy centres are large and very demanding on the design of accelerators and guiding systems.

Advanced Oncotherapy (AVO), a London company that builds on and markets CERN’s expertise in medical particle accelerators, aims to change the picture. Their highly adaptable Linac Image-Guided Hadron Technology (LIGHT) accelerator, based on CERN technology and developed by ADAM, AVO’s Geneva-based subsidiary, provides a proton beam allowing the delivery of ultra-high dose rates to deep-seated tumours. LIGHT reached the maximum treatment energy of 230 MeV at the STFC Daresbury site (United Kingdom) on 26 September and is getting ready to treat its first patients in collaboration with University Hospital Birmingham (UHB).

LIGHT, the first linear accelerator used for proton cancer treatment worldwide, relies on components and designs developed by CERN, ENEA and the TERA Foundation for the three successive sections of an accelerator that would be both affordable and dense, an important requirement for the medical sector. Components of note include LIGHT’s radio-frequency quadrupole (designed by CERN), which contributes to its compact design, as well as ten radio-frequency modules composed of side-coupled accelerating cavities based on a TERA Foundation design. Each module can be switched on and off individually to vary the beam energy 200 times per second, depending on the depth of the tumour layer. The linac design reduces beam losses, stray radiation and, consequently, the volume of shielding material required. This innovative design allows the linear accelerator to generate an extremely focused beam of 70 to 230 MeV and to target tumours in three dimensions, by varying the depth at which the radiation dose is delivered much faster than existing circular accelerators can.

Seven years after the first 16-metre-long prototype was built and tested at LHC Point 2, this novel oncological linac will treat its first patients at Daresbury during the second half of 2023. Of course, this is only the beginning of what is bound to be a long journey, as AVO hopes their new 25-metre-long design will change the landscape of cancer treatment over the long term by enabling the development of new dose delivery methods based on faster energy variation and a more focused beam.

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