For 100 years, Mayo Clinic Proceedings has helped shape the course of modern medicine - publishing discoveries that move from the page to the bedside and improve care for patients around the world. As the journal approaches its centennial in April 2026, Mayo Clinic is marking the milestone with events, exhibitions and special publications celebrating a century of scientific rigor, collaboration and impact.
Rooted in the same spirit that drives Bold. Forward., Mayo Clinic's strategy to transform healthcare, Mayo Clinic Proceedings continues to connect discovery to delivery - advancing the science and practice of medicine, helping ensure that knowledge translates into better outcomes for patients everywhere.
First published in April 1926 as the Bulletin of the Mayo Clinic and Mayo Foundation, Mayo Clinic Proceedingsis a leading journal of general and internal medicine that reaches millions of readers worldwide, with more than 7 million article downloads in 2025 and a journal Impact Factor of 6.7. It ranks among the top 10% of general and internal medicine journals internationally.
Since January 2025, the journal has been highlighting, in special articles and historical content, its 100-year commitment to research that has transformed medical science and practice. On April 25, a centennial reception will be held on the Rochester campus.
"Mayo Clinic Proceedingsbegan as an internal publication, but its spirit and intent always were expansive," says Karl Nath, M.B., Ch.B., M.D., Mayo Clinic Proceedings editor-in-chief. "It was meant to share knowledge, to educate and to improve care - values that continue to guide it a century later. As we enter our second century, we remain committed to publishing content that informs, inspires and advances healthcare."
Evolved from a newsletter to an internationally renowned journal
Mayo Clinic Proceedings had its start in the early years of Mayo Clinic's transformation from a family medical practice into an internationally renowned clinic. During weekly staff meetings in the 1920s, the Mayo brothers, William A. Mayo, M.D., and Charles W. Mayo, M.D., sat in the front row as colleagues presented cases and discussed new approaches to patient care. To share this knowledge more broadly, they enlisted Maude Mellish Wilson, the clinic's first institutional librarian, to summarize the meetings. Wilson's newsletter quickly evolved into Mayo Clinic Proceedings.
Throughout its history, Mayo Clinic Proceedings has captured landmark moments in medicine, from the introduction of insulin therapy in the 1920s to pioneering research on cortisone by Mayo Clinic researchers who later received the Nobel Prize. Since the COVID-19 pandemic began in 2020, the journal has published more than 500 related studies, including early findings on infection risks among healthcare personnel and post-COVID-19 syndromes.
The journal, which has featured cutting-edge work on artificial intelligence in cardiology, digital health innovation and physician well-being, has two open-access expansion journals: Mayo Clinic Proceedings: Innovations, Quality & Outcomes and Mayo Clinic Proceedings: Digital Health. Both have been accepted by Clarivate for Impact Factor ratings, a marker of influence and quality in academic publishing.
Podcasts, exhibitions and a commemorative edition
There are several events and publications planned to celebrate the centennial, including:
- A virtual historical exhibit curated by Mayo Clinic Archives
