Sugars are key biomolecules in living organisms, as they form the backbone of DNA and RNA and play a fundamental role in metabolic processes. In theories of the origin of life, sugars are also essential for the synthesis of the first nucleic acids. Despite their importance, one of the major questions in origin-of-life research is how the first sugars formed on Earth, since laboratory experiments show that they do not form in enough quantities under prebiotic conditions. Sugars such as ribose and glucose have previously been detected in meteorite and asteroid samples, suggesting that some of these molecules may have originated in the primordial molecular cloud from which our Solar System formed. However, until now, no sugar had ever been directly detected in the interstellar medium.
An international team led by CAB researcher Izaskun Jiménez-Serra has now identified the first sugar in interstellar space: erythrulose. This molecule is the only possible four-carbon ketose, and on Earth it is commonly found in raspberries and sunless tanning products. Erythrulose was detected toward the molecular cloud G+0.693−0.027, located near the centre of our Galaxy, the Milky Way. The discovery was made possible by ultra-sensitive, broadband spectroscopic surveys carried out with the 40-m Yebes radio telescope and the 30-m telescope of the Institute for Radio Astronomy in the Millimeter Range (IRAM).
The team identified 12 spectral lines matching the laboratory spectrum of erythrulose measured at the University of the Basque Country. The study also shows that this sugar is at least eight times more abundant than similar three-carbon sugars, none of which were detected in the same region. "This finding was unexpected, as the prevailing view in astrochemistry is that interstellar molecules grow in size through the sequential addition of carbon atoms", says Izaskun Jimenez Serra (CAB), leading author of this work.
Working in collaboration with chemists from the University of Extremadura and Radboud University (the Netherlands), the CAB team discovered that erythrulose can form within interstellar ices from simpler two-carbon alcohols and aldehydes.
Based on the abundance of erythrulose measured in the G+0.693−0.027 molecular cloud, the researchers estimate that between 0.5 and 50 million tonnes of this sugar could have reached Earth's surface during the Late Heavy Bombardment, which occurred approximately 4.1 to 3.8 billion years ago. The presence of erythrulose in interstellar space therefore provides an alternative source of sugars that may have contributed to the emergence of the first metabolic and replication processes on the early Earth.
"The detection of erythrulose is very exciting because it opens up the possibility of discovering in space other sugars such as ribose, which is part of RNA, and other important molecules for the origin of life," says Carlos Briones, co-author of the study.
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