In a recent study published on Nutrients, a research group led by Prof. ZHENG Zhiming from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (CAS) has found a novel function of vitamin K2 - regulating mitochondrial membrane potential and alleviating oxidative stress, thus repairing mitochondrial dysfunction and inhibiting nerve cell damage caused by 6-hydroxydopamine (6-OHDA).
The antioxidant function of vitamin K2 is a powerful neuroprotective molecule, but its mechanism has not been fully elucidated. 6-OHDA is a nerve agent that causes degeneration of dopamine neurons, which can lead to mitochondrial damage and nerve cell death. It is often used in the pathogenesis of Parkinson's and other neurodegenerative diseases.
In this research, scientists found that vitamin K2 can inhibit nerve cell damage caused by 6-OHDA by protecting mitochondria.
Vitamin K2 plays the role of the main switch of apoptosis by up-regulating the expression of B-cell lymphoma-2 (one of oncogenes in apoptosis research) and down-regulating the expression of Bax (the most important apoptotic gene in human body), thus regulating the mitochondrial membrane potential and reactive oxygen species levels and alleviating oxidative stress, according to Dr.TANG Hengfang, first author of the study.
