JAMA Network
About The Study: This study estimated the impact of replacing universal hepatitis B virus (HBV) birth-dose vaccination with a targeted recommendation on neonatal and subsequent chronic HBV infections in the U.S. The findings indicate that the targeted birth-dose vaccine recommendation will likely increase neonatal infections unless maternal screening rises substantially or vaccination coverage among infants of unscreened mothers exceeds current levels. As historic data show such improvements are unlikely, these findings underscore the continued importance of universal screening and vaccination as complementary safeguards.
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