Oak Brook, IL – Volume 41 of SLAS Technology includes one review, four original research articles, and two entries from the Special Issue on Revolutionizing Transcriptomics from Single-Cell Insights to RNA-Based Interventions.
Review
- Electrospinning Processes: Properties, Applications, Sensor Integration Nanofiber and Biomaterials
This review examines the electrospinning process and the parameters that govern fiber morphology and structure. It also reviews the properties and diverse applications of electrospun nanofibers, from tissue engineering and filtration to wearable biosensors and defense, while highlighting how fillers can be incorporated to enhance functionality.
Original Research
- Cell-State-Resolved Transcriptomic Analysis Reveals Macrophage-Centered Pyroptosis-Related Inflammatory Programs in Age-Related Macular Degeneration
Single-cell RNA sequencing of human retinal pigment epithelium/choroid tissue reveals that pyroptosis-related inflammatory programs in age-related macular degeneration are concentrated in specific macrophage states, with NLRP3, IRF1, STAT3, and NEAT1 identified as candidate regulatory features supported by a choroidal neovascularization mouse model.
- AI-Guided Computational Design of Synthetic Microbiota for Next-Generation Immunomodulatory Applications
Researchers present Synthetic Immune Modulation Transformer, an immune-aware deep learning framework that combines graph and multimodal transformers with a novel Immune-Aware Constraint Layer to model microbe–microbe interactions and design synthetic microbiota that remain immunologically plausible.
- Thermal Stability and Preliminary Antimicrobial Evaluation of Polylysine-Glutathione Mixtures
The authors evaluate a polylysine-glutathione ionic complex formed by electrostatic self-assembly, which shows possession of thermal stability and synergistic antibacterial and antifungal activity, including a 93.7% inhibition rate against Candida albicans at its minimum inhibitory concentration.
- MINPP1, HES4 and SLCO5A1 as Core Signature Genes Mediating the Effects of Type 2 Diabetes on Coronary Artery Bypass Grafting
By integrating bioinformatics, machine learning, clinical validation, and in vitro experiments, researchers identified MINPP1, HES4, and SLCO5A1 as core signature genes that mediate the adverse effects of type 2 diabetes on coronary artery bypass grafting outcomes, with diagnostic models showing excellent calibration and clinical net benefit.
Special Issues
- Revolutionizing Transcriptomics from Single-Cell Insights to RNA-Based Interventions
This Special Issue on systems genetics examines gene and molecular interaction networks, utilizing high-throughput sequencing and multi-omics technologies to understand how genetic networks influence phenotypes. It emphasizes the significance of personalized medicine, therapeutic target discovery and biomarker identification through integrated genomic and epigenomic approaches. Volume 41 of SLAS Technology contains the following articles from the Special Issue:
All active SLAS Discovery and SLAS Technology calls for papers are available at: https://www.slas.org/publications/call-for-papers/
This volume of SLAS Technology is available at https://www.slas-technology.org/issue/S2472-6303(26)X2004-0
